Integrative Vascular Biology Laboratory Carlson, Room 108 Phone:  303-735-3605 Fax:  303-492-6778

Research Interests

• The effects of aging, cardiovascular and metabolic risk factors, and habitual physical activity on vascular endothelial function.

Personnel

• Director: Christopher A. DeSouza, Ph.D.


• Medical Director: Brian Stauffer, M.D.


• Laboratory Director: Jared Greiner, M.S.


• Postdoctoral and Predoctoral Fellows as well as graduate and undergraduate students.

Current Research Projects

• Influence of age, obesity, exercise, and oxidative stress on the endothelin-1 system.


• HIV-1 infection, vascular endothelial function, and exercise.


• Effects of nebivolol on ET-1 vasoconstrictor tone.


• Nebivolol and endothelial regulation of fibrinolysis.


• Overweight/obesity and vascular progenitor cell function.

Videos

Recent Publications

• Diehl KJ, Stauffer BL, Greiner JJ, Weil BR, DeSouza CA. Nitric oxide-mediated endothelium-dependent vasodilation is impaired with borderline high-LDL cholesterol. Clinical and Translational Science 5: 21-26, 2012.


• Kushner EJ, MacEneaney OJ, Weil BR, Greiner JJ, Stauffer BL, DeSouza CA. Aging is associated with a proapoptotic endothelial progenitor cell phenotype. Journal of Vascular Research 48: 408-414, 2011.


• MacEneaney OJ, Connick E, DeSouza CA. Effects of HIV-1 gp120 and protease inhibitors on apoptotic susceptibility of CD34+ hematopoietic progenitor cells. Journal of Acquired Immune Deficiency Syndrome 56: e49-50, 2011.


• MacEneaney OJ, DeSouza CA, Weil BR, Kushner EJ, Van Guilder GP, Mestek ML, Greiner JJ, Stauffer BL. Prehypertension and endothelial progenitor cell function. Journal of Human Hypertension 25: 57-62, 2011.


• Weil BR, MacEneaney OJ, Stauffer BL, DeSouza CA. Habitual short sleep duration and circulating endothelial progenitor cells. Journal of Cardiovascular Disease Research 2: 110-114, 2011.


• Weil BR, Stauffer BL, Greiner JJ, DeSouza CA. Prehypertension in associated with impaired nitric oxide-mediated endothelium-dependent vasodilation in sedentary adults. American Journal of Hypertension 24: 976-981, 2011.


• Weil BR, Stauffer BL, Mestek ML, DeSouza CA. Influence of abdominal obesity on vascular endothelial function in overweight/obese adult men. Obesity 19: 1742-1746, 2011.


• Weil BR, Westby CM, Van Guilder GP, Greiner JJ, Stauffer BL, DeSouza CA. Enhanced endothelin-1 system activity with overweight and obesity. American Journal of Physiology 301: H689-695, 2011.


• Westby CM, Weil BR, Greiner JJ, Stauffer BL, DeSouza CA. Endothelin-1 vasoconstriction and the age-related decline in endothelium-dependent vasodilation in men. Clinical Science 120: 485-491, 2011.